![]() The Shoklo Malaria Research Unit is part of the Mahidol Oxford University Research Unit, supported by the Wellcome Trust of Great Britain. Requests for access to data should be submitted through Requests will be reviewed by a Data Access Committee to ensure that use of data is within the terms of consent and ethics approval.įunding: Part of the work presented, the ASAP studies, was supported by the Malaria in Pregnancy (MiP) Consortium, which is funded through a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine, United Kingdom. The work is made available under the Creative Commons CC0 public domain dedication.ĭata Availability: The complete individual patient-level data data are available through the World Wide Antimalarial Resistance Network (WWARN). This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: JAccepted: MaPublished: May 2, 2017 George's, University of London, UNITED KINGDOM PLoS Med 14(5):Īcademic Editor: Sanjeev Krishna, St. (2017) First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies. In this meta-analysis of prospective observational studies, we summarize all available safety data on the effect of artemisinin exposure in the first trimester and compare the risk of miscarriage, stillbirth, and major congenital anomaly for pregnancies treated with artemisinin, quinine, or no antimalarials in the first trimester.Ĭitation: Dellicour S, Sevene E, McGready R, Tinto H, Mosha D, Manyando C, et al.Animal embryotoxicity data and the paucity of safety data in human pregnancies have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in life-saving circumstances, yet in malaria endemic countries, many early pregnancies are advertently or inadvertently exposed to ACTs.Artemisinin combination therapies (ACTs), the most efficacious antimalarials available, are the recommended first-line treatment for Plasmodium falciparum malaria. ![]()
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